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The absence of Pin1 has been associated with age-dependent tau hyperphosphorylation and neurodegeneration [126]

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(PDF 2629 kb) Human blood was processed for GSH analysis by HPLC (i.e., by collection into tubes containing K 3 EDTA/NEM310 and deproteination by addition of TCA15 (as described in the PROCEDURE))

The nanoUPLC was coupled online through a nanoESI emitter (10 m tip, New Objective) to a quadrupole orbitrap mass spectrometer (Orbitrap Exploris 480, Thermo Fisher Scientific) using a FlexIon nanospray apparatus (Proxeon)

Various animal models of traumatic stress are used to produce behavioral, molecular, and physiological alterations that resemble many of the alterations observed in PTSD patients